The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. [provided by RefSeq, Apr 2022]
Transcription factors with Perturb-seq knockdown data for ATP11A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP11A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP11A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:112,443,518–112,444,440 | 245.9 kb | Distal (>10kb) Multiome | 229 | |
| chr13:112,587,337–112,588,413 | 102.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr13:112,606,168–112,606,859 | 83.5 kb | Distal (>10kb) Multiome | 517 | |
| chr13:112,689,000–112,690,944 | 2 bp | At TSS Multiome | 778 | |
| chr13:112,711,516–112,712,479 | 21.9 kb | Distal (>10kb) Multiome | 761 | |
| chr13:112,885,816–112,886,312 | 196.0 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr13:112,893,373–112,895,600 | 204.2 kb | Distal (>10kb) Multiome HiCAR | 634 | |
| chr13:112,906,009–112,906,659 | 216.3 kb | Distal (>10kb) Multiome | 327 | |
| chr13:112,942,743–112,944,278 | 252.9 kb | Distal (>10kb) Multiome | 632 | |
| chr13:112,968,613–112,969,532 | 279.1 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the ATP11A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.