This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for ATG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,136,789–112,137,394 | 424.8 kb | Distal (>10kb) Multiome HiCAR | 233 | |
| chr3:112,293,399–112,294,560 | 268.1 kb | Distal (>10kb) Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 258.5 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr3:112,321,650–112,322,563 | 239.8 kb | Distal (>10kb) Multiome | 210 | |
| chr3:112,332,830–112,333,873 | 228.7 kb | Distal (>10kb) Multiome | 281 | |
| chr3:112,390,974–112,391,552 | 170.6 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 161.4 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 194 bp | At TSS Multiome | 967 | |
| chr3:112,564,307–112,565,127 | 2.4 kb | Proximal (<10kb) | 17 | |
| chr3:112,566,578–112,566,873 | 4.7 kb | Proximal (<10kb) | 8 | |
| chr3:112,785,378–112,786,966 | 224.3 kb | Distal (>10kb) Multiome | 290 | |
| chr3:113,018,819–113,020,010 | 457.7 kb | Distal (>10kb) Multiome HiCAR | 965 |
Genomic view of the ATG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.