This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ATG2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:96,191,842–96,192,712 | 171.1 kb | Distal (>10kb) Multiome | 49 | |
| chr14:96,362,070–96,362,551 | 789 bp | At TSS | 276 | |
| chr14:96,362,703–96,364,312 | 74 bp | At TSS Multiome | 728 | |
| chr14:96,391,216–96,392,835 | 28.6 kb | Distal (>10kb) Multiome | 787 | |
| chr14:96,461,283–96,462,546 | 98.7 kb | Distal (>10kb) Multiome | 392 | |
| chr14:96,501,754–96,503,092 | 139.0 kb | Distal (>10kb) Multiome | 986 | |
| chr14:96,583,910–96,584,894 | 221.1 kb | Distal (>10kb) Multiome | 345 | |
| chr14:96,592,395–96,593,217 | 229.4 kb | Distal (>10kb) Multiome | 226 |
Genomic view of the ATG2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.