Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATF7IP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATF7IP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATF7IP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:10,180,776–10,182,442 | 204.3 kb | Distal (>10kb) Multiome | 514 | |
| chr16:10,282,522–10,283,683 | 102.7 kb | Distal (>10kb) Multiome | 60 | |
| chr16:10,385,788–10,386,451 | 12 bp | At TSS Multiome | 964 | |
| chr16:10,579,792–10,580,982 | 194.6 kb | Distal (>10kb) Multiome | 830 | |
| chr16:10,621,860–10,622,627 | 236.2 kb | Distal (>10kb) Multiome | 241 | |
| chr16:10,743,473–10,744,692 | 358.1 kb | Distal (>10kb) Multiome | 1045 |
Genomic view of the ATF7IP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.