A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATAD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATAD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATAD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:123,156,604–123,157,953 | 239.2 kb | Distal (>10kb) Multiome | 1083 | |
| chr8:123,160,441–123,161,547 | 235.8 kb | Distal (>10kb) Multiome | 590 | |
| chr8:123,205,121–123,205,789 | 191.0 kb | Distal (>10kb) Multiome | 298 | |
| chr8:123,207,081–123,207,716 | 189.1 kb | Distal (>10kb) Multiome | 96 | |
| chr8:123,235,684–123,236,295 | 160.4 kb | Distal (>10kb) Multiome | 110 | |
| chr8:123,240,791–123,241,581 | 155.1 kb | Distal (>10kb) Multiome | 784 | |
| chr8:123,273,286–123,275,625 | 121.7 kb | Distal (>10kb) Multiome | 970 | |
| chr8:123,395,126–123,395,524 | 922 bp | At TSS | 252 | |
| chr8:123,395,612–123,397,193 | 169 bp | At TSS Multiome | 1096 | |
| chr8:123,416,006–123,417,726 | 20.1 kb | Distal (>10kb) Multiome | 823 | |
| chr8:123,479,357–123,480,359 | 83.3 kb | Distal (>10kb) Multiome | 179 | |
| chr8:123,539,997–123,542,004 | 145.0 kb | Distal (>10kb) Multiome | 699 | |
| chr8:123,678,684–123,679,495 | 282.9 kb | Distal (>10kb) Multiome | 51 | |
| chr8:123,679,596–123,680,360 | 283.5 kb | Distal (>10kb) Multiome | 85 |
Genomic view of the ATAD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.