Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ASRGL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASRGL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASRGL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,123,661–62,124,441 | 213.6 kb | Distal (>10kb) Multiome | 619 | |
| chr11:62,337,140–62,338,142 | 27 bp | At TSS Multiome | 611 | |
| chr11:62,382,190–62,383,008 | 45.1 kb | Distal (>10kb) Multiome | 36 | |
| chr11:62,460,403–62,461,004 | 123.3 kb | Distal (>10kb) Multiome | 20 | |
| chr11:62,508,289–62,508,878 | 171.1 kb | Distal (>10kb) Multiome | 499 | |
| chr11:62,542,658–62,543,488 | 205.5 kb | Distal (>10kb) Multiome | 537 | |
| chr11:62,545,051–62,547,562 | 209.6 kb | Distal (>10kb) Multiome | 889 | |
| chr11:62,553,213–62,553,741 | 216.0 kb | Distal (>10kb) Multiome | 489 | |
| chr11:62,555,905–62,556,742 | 218.8 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 223.2 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 224.6 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 236.6 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 254.3 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 264.5 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 275.4 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 284.6 kb | Distal (>10kb) Multiome | 964 |
Genomic view of the ASRGL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.