This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked cognitive disability and epilepsy. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ARX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:24,999,493–24,999,917 | 7.3 kb | Proximal (<10kb) | 66 | |
| chrX:25,003,120–25,003,351 | 3.8 kb | Proximal (<10kb) | 61 | |
| chrX:25,004,448–25,005,169 | 2.0 kb | Proximal (<10kb) | 82 | |
| chrX:25,007,019–25,007,702 | at TSS | At TSS | 128 | |
| chrX:25,012,445–25,013,314 | 5.3 kb | Proximal (<10kb) | 173 | |
| chrX:25,015,537–25,016,433 | 8.4 kb | Proximal (<10kb) | 282 | |
| chrX:25,020,333–25,021,383 | 4.4 kb | Proximal (<10kb) | 288 | |
| chrX:25,022,748–25,023,164 | 6.8 kb | Proximal (<10kb) | 78 |
Genomic view of the ARX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.