Enables several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARRDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARRDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARRDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,316,104–137,316,916 | 289.4 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 198.5 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 182.4 kb | Distal (>10kb) Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 164.1 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 151.6 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 146.3 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 143.8 kb | Distal (>10kb) Multiome | 284 | |
| chr9:137,551,136–137,552,512 | 53.9 kb | Distal (>10kb) Multiome | 756 | |
| chr9:137,578,523–137,579,553 | 26.7 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 15.1 kb | Distal (>10kb) Multiome | 623 | |
| chr9:137,604,440–137,607,003 | 245 bp | At TSS Multiome | 675 | |
| chr9:137,618,064–137,619,880 | 13.3 kb | Distal (>10kb) Multiome | 867 | |
| chr9:137,723,975–137,724,439 | 118.5 kb | Distal (>10kb) Multiome | 115 | |
| chr9:137,732,255–137,733,025 | 127.0 kb | Distal (>10kb) Multiome | 20 | |
| chr9:137,851,599–137,852,229 | 246.2 kb | Distal (>10kb) Multiome | 104 | |
| chr9:137,876,903–137,879,307 | 271.9 kb | Distal (>10kb) Multiome | 452 |
Genomic view of the ARRDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.