This locus represents naturally occurring readthrough transcription among the adjacent armadillo repeat containing, X-linked 5 (ARMCX5), G protein-coupled receptor associated sorting proteins 1 and 2 (GPRASP1 and GPRASP2), basic helix-loop-helix family member b9 (BHLHB9), and long intergenic non-protein coding RNA 630 (LINC00630) genes on chromosome X. Transcripts may make use of multiple alternative promoters and polyadenylation signals in this region. Readthrough transcripts may produce proteins identical to the proteins encoded by GPRASP2 or BHLHB9. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for ARMCX5-GPRASP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMCX5-GPRASP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMCX5-GPRASP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:102,516,273–102,517,096 | 195.7 kb | Distal (>10kb) Multiome | 197 | |
| chrX:102,599,050–102,600,172 | 113.0 kb | Distal (>10kb) Multiome | 573 | |
| chrX:102,651,041–102,651,962 | 61.1 kb | Distal (>10kb) Multiome | 96 | |
| chrX:102,712,007–102,713,630 | 65 bp | At TSS Multiome | 188 | |
| chrX:102,720,542–102,721,187 | 8.0 kb | Proximal (<10kb) | 247 | |
| chrX:102,745,604–102,746,582 | 33.5 kb | Distal (>10kb) Multiome | 103 | |
| chrX:102,768,555–102,769,457 | 56.6 kb | Distal (>10kb) Multiome | 420 |
Genomic view of the ARMCX5-GPRASP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.