This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARMCX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMCX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMCX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:101,348,449–101,349,149 | 274.3 kb | Distal (>10kb) Multiome | 567 | |
| chrX:101,390,531–101,391,386 | 232.2 kb | Distal (>10kb) Multiome | 762 | |
| chrX:101,407,491–101,408,749 | 215.0 kb | Distal (>10kb) Multiome | 745 | |
| chrX:101,417,975–101,418,807 | 204.7 kb | Distal (>10kb) Multiome | 296 | |
| chrX:101,484,988–101,486,015 | 137.7 kb | Distal (>10kb) Multiome | 155 | |
| chrX:101,550,213–101,551,613 | 72.5 kb | Distal (>10kb) Multiome | 249 | |
| chrX:101,617,258–101,618,125 | 5.5 kb | Proximal (<10kb) Multiome | 435 | |
| chrX:101,622,792–101,623,603 | 6 bp | At TSS Multiome | 410 | |
| chrX:101,624,116–101,624,273 | 990 bp | At TSS | 60 | |
| chrX:101,629,764–101,630,044 | 6.6 kb | Proximal (<10kb) | 13 |
Genomic view of the ARMCX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.