This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for ARL6IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL6IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL6IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:18,789,852–18,790,674 | 11.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr16:18,800,801–18,802,152 | 144 bp | At TSS Multiome | 1139 | |
| chr16:18,925,547–18,927,198 | 125.0 kb | Distal (>10kb) Multiome | 788 | |
| chr16:18,983,732–18,984,444 | 182.4 kb | Distal (>10kb) Multiome | 817 | |
| chr16:19,067,380–19,068,213 | 266.1 kb | Distal (>10kb) Multiome | 982 | |
| chr16:19,086,334–19,086,896 | 285.1 kb | Distal (>10kb) Multiome | 852 |
Genomic view of the ARL6IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.