This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,729,775–64,730,315 | 284.1 kb | Distal (>10kb) Multiome | 115 | |
| chr11:64,742,520–64,743,124 | 271.2 kb | Distal (>10kb) Multiome | 501 | |
| chr11:64,759,882–64,760,354 | 254.1 kb | Distal (>10kb) Multiome | 172 | |
| chr11:64,777,493–64,779,271 | 236.5 kb | Distal (>10kb) Multiome | 859 | |
| chr11:64,802,650–64,803,485 | 210.8 kb | Distal (>10kb) Multiome | 522 | |
| chr11:64,809,807–64,811,090 | 203.5 kb | Distal (>10kb) Multiome | 702 | |
| chr11:64,844,075–64,845,264 | 169.4 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr11:64,846,953–64,847,598 | 166.9 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr11:64,877,434–64,879,352 | 135.4 kb | Distal (>10kb) Multiome | 980 | |
| chr11:64,887,785–64,888,374 | 126.1 kb | Distal (>10kb) Multiome | 633 | |
| chr11:64,916,057–64,917,940 | 96.8 kb | Distal (>10kb) Multiome | 873 | |
| chr11:64,924,041–64,924,916 | 89.7 kb | Distal (>10kb) Multiome HiCAR | 808 | |
| chr11:64,971,835–64,972,454 | 42.0 kb | Distal (>10kb) Multiome | 265 | |
| chr11:65,013,538–65,014,838 | 141 bp | At TSS Multiome | 980 | |
| chr11:65,027,243–65,027,944 | 13.4 kb | Distal (>10kb) Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 26.9 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 70.1 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 82.3 kb | Distal (>10kb) Multiome | 1061 | |
| chr11:65,111,466–65,113,404 | 97.7 kb | Distal (>10kb) Multiome | 919 | |
| chr11:65,116,528–65,118,298 | 103.6 kb | Distal (>10kb) Multiome | 973 | |
| chr11:65,121,474–65,122,848 | 108.1 kb | Distal (>10kb) Multiome | 817 | |
| chr11:65,134,120–65,135,530 | 120.8 kb | Distal (>10kb) Multiome | 997 | |
| chr11:65,180,773–65,182,676 | 167.5 kb | Distal (>10kb) Multiome | 832 | |
| chr11:65,184,109–65,184,542 | 170.2 kb | Distal (>10kb) Multiome | 85 | |
| chr11:65,213,383–65,213,853 | 199.5 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 211.5 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 247.7 kb | Distal (>10kb) Multiome | 777 |
Genomic view of the ARL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.