Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ARHGEF12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,039,936–120,040,648 | 296.1 kb | Distal (>10kb) Multiome | 29 | |
| chr11:120,057,897–120,058,380 | 278.2 kb | Distal (>10kb) Multiome | 90 | |
| chr11:120,168,771–120,169,627 | 167.2 kb | Distal (>10kb) Multiome | 478 | |
| chr11:120,210,679–120,211,521 | 125.5 kb | Distal (>10kb) Multiome | 606 | |
| chr11:120,236,598–120,237,182 | 99.6 kb | Distal (>10kb) Multiome | 249 | |
| chr11:120,255,150–120,255,776 | 81.0 kb | Distal (>10kb) Multiome | 143 | |
| chr11:120,324,948–120,325,789 | 11.1 kb | Distal (>10kb) Multiome | 665 | |
| chr11:120,334,912–120,335,251 | 1.2 kb | Proximal (<10kb) | 294 | |
| chr11:120,335,703–120,337,153 | 76 bp | At TSS Multiome | 976 | |
| chr11:120,510,928–120,512,148 | 175.1 kb | Distal (>10kb) Multiome | 448 | |
| chr11:120,527,165–120,527,924 | 191.1 kb | Distal (>10kb) Multiome | 168 | |
| chr11:120,564,037–120,565,284 | 227.7 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the ARHGEF12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.