Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARHGEF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,706,740–41,707,217 | 176.2 kb | Distal (>10kb) Multiome | 420 | |
| chr19:41,859,455–41,860,753 | 23.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:41,873,024–41,873,462 | 9.7 kb | Proximal (<10kb) | 501 | |
| chr19:41,882,803–41,883,350 | at TSS | At TSS | 386 | |
| chr19:41,883,883–41,884,651 | 1.1 kb | Proximal (<10kb) Multiome | 917 | |
| chr19:41,887,651–41,888,254 | 4.8 kb | Proximal (<10kb) Multiome | 553 | |
| chr19:41,927,700–41,928,620 | 45.0 kb | Distal (>10kb) Multiome | 277 | |
| chr19:41,930,462–41,931,200 | 47.8 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr19:41,957,648–41,959,799 | 75.4 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr19:41,993,779–41,994,412 | 111.0 kb | Distal (>10kb) Multiome | 360 | |
| chr19:41,998,577–41,999,349 | 115.6 kb | Distal (>10kb) Multiome | 292 | |
| chr19:42,075,557–42,076,657 | 192.8 kb | Distal (>10kb) Multiome | 846 | |
| chr19:42,095,735–42,096,278 | 212.8 kb | Distal (>10kb) Multiome | 107 | |
| chr19:42,132,949–42,133,545 | 250.1 kb | Distal (>10kb) Multiome | 447 | |
| chr19:42,176,787–42,177,398 | 293.9 kb | Distal (>10kb) Multiome | 381 | |
| chr19:43,827,133–43,827,702 | 1944.1 kb | Distal (>10kb) Multiome HiCAR | 593 |
Genomic view of the ARHGEF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.