This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ARHGDIA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGDIA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGDIA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,636,404–81,637,301 | 234.3 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 223.1 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 218.2 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 204.7 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 187.4 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 168.0 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 159.1 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 38.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 10.5 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,867,228–81,867,711 | 3.6 kb | Proximal (<10kb) | 680 | |
| chr17:81,867,733–81,868,293 | 3.0 kb | Proximal (<10kb) | 676 | |
| chr17:81,868,421–81,868,978 | 2.8 kb | Proximal (<10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 86 bp | At TSS Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 20.4 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 40.2 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 46.8 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 52.2 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 56.6 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 66.0 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 88.4 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 96.7 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 106.3 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 148.8 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 151.7 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 160.6 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 166.3 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 180.4 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 194.5 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 227.2 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 232.2 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the ARHGDIA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.