Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:31,993,739–31,995,074 | 82.7 kb | Distal (>10kb) Multiome | 129 | |
| chr14:32,073,674–32,073,845 | 3.1 kb | Proximal (<10kb) | 180 | |
| chr14:32,075,773–32,078,300 | 442 bp | At TSS Multiome | 1050 | |
| chr14:32,200,996–32,202,373 | 124.1 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr14:32,202,830–32,204,312 | 126.2 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr14:32,224,855–32,226,641 | 148.1 kb | Distal (>10kb) Multiome HiCAR | 350 |
Genomic view of the ARHGAP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.