Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for ARHGAP29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:94,045,555–94,046,076 | 191.8 kb | Distal (>10kb) Multiome HiCAR | 556 | |
| chr1:94,148,998–94,149,784 | 88.3 kb | Distal (>10kb) Multiome | 44 | |
| chr1:94,236,814–94,238,189 | 6 bp | At TSS Multiome | 709 | |
| chr1:94,239,398–94,240,097 | 1.8 kb | Proximal (<10kb) | 46 | |
| chr1:94,247,152–94,248,342 | 10.1 kb | Distal (>10kb) Multiome | 521 | |
| chr1:94,327,061–94,327,698 | 89.9 kb | Distal (>10kb) Multiome | 243 | |
| chr1:94,342,282–94,342,957 | 105.0 kb | Distal (>10kb) Multiome | 83 | |
| chr1:94,417,844–94,419,337 | 180.7 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the ARHGAP29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.