Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Located in cytosol and endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGAP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:147,480,463–147,482,217 | 250.8 kb | Distal (>10kb) Multiome | 379 | |
| chr4:147,522,274–147,523,482 | 209.0 kb | Distal (>10kb) Multiome | 84 | |
| chr4:147,616,952–147,618,103 | 114.7 kb | Distal (>10kb) Multiome | 744 | |
| chr4:147,683,720–147,684,759 | 47.9 kb | Distal (>10kb) Multiome | 824 | |
| chr4:147,724,426–147,725,089 | 7.0 kb | Proximal (<10kb) | 48 | |
| chr4:147,730,309–147,730,676 | 1.4 kb | Proximal (<10kb) | 50 | |
| chr4:147,730,889–147,733,228 | 45 bp | At TSS Multiome | 724 | |
| chr4:147,733,333–147,733,626 | 1.2 kb | Proximal (<10kb) | 58 | |
| chr4:147,733,972–147,734,325 | 1.9 kb | Proximal (<10kb) | 83 | |
| chr4:147,737,621–147,738,019 | 5.5 kb | Proximal (<10kb) | 156 | |
| chr4:147,924,252–147,925,592 | 192.9 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the ARHGAP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.