Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:65,813,612–65,814,373 | 1805.9 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr14:67,359,034–67,360,833 | 259.9 kb | Distal (>10kb) Multiome | 891 | |
| chr14:67,427,006–67,427,629 | 192.6 kb | Distal (>10kb) Multiome | 288 | |
| chr14:67,514,900–67,515,814 | 104.6 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,532,784–67,533,987 | 86.6 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 77.9 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 19.7 kb | Distal (>10kb) Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 95 bp | At TSS Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 54.9 kb | Distal (>10kb) Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 74.9 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 109.4 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 196.7 kb | Distal (>10kb) Multiome | 712 | |
| chr14:67,819,625–67,820,281 | 199.9 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the ARG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.