Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization; mitophagy; and protein localization to phagophore assembly site. Located in several cellular components, including nucleolus; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARFIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,234,062–6,235,769 | 246.4 kb | Distal (>10kb) Multiome | 776 | |
| chr11:6,237,822–6,239,512 | 242.4 kb | Distal (>10kb) Multiome | 164 | |
| chr11:6,249,589–6,250,614 | 231.3 kb | Distal (>10kb) Multiome | 268 | |
| chr11:6,251,174–6,251,654 | 229.9 kb | Distal (>10kb) Multiome | 193 | |
| chr11:6,258,709–6,260,456 | 221.6 kb | Distal (>10kb) Multiome | 283 | |
| chr11:6,267,833–6,269,111 | 212.8 kb | Distal (>10kb) Multiome | 142 | |
| chr11:6,280,060–6,282,351 | 200.5 kb | Distal (>10kb) Multiome | 214 | |
| chr11:6,318,947–6,321,304 | 161.3 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,353,367–6,353,932 | 127.7 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,367,341–6,367,799 | 113.8 kb | Distal (>10kb) Multiome | 55 | |
| chr11:6,389,605–6,390,990 | 91.0 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 75.9 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 62.2 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 12.1 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 7.3 kb | Proximal (<10kb) Multiome | 591 | |
| chr11:6,475,549–6,476,180 | 5.1 kb | Proximal (<10kb) | 94 | |
| chr11:6,480,885–6,482,114 | 75 bp | At TSS Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 16.0 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 105.7 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 122.4 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 125.8 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 131.0 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 138.1 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 149.2 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 174.5 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 202.1 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the ARFIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.