Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARFIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,515,941–152,516,444 | 263.7 kb | Distal (>10kb) Multiome | 126 | |
| chr4:152,535,271–152,537,069 | 243.7 kb | Distal (>10kb) Multiome | 955 | |
| chr4:152,540,175–152,541,082 | 239.4 kb | Distal (>10kb) Multiome | 203 | |
| chr4:152,619,935–152,621,307 | 159.5 kb | Distal (>10kb) Multiome | 92 | |
| chr4:152,679,625–152,680,356 | 100.0 kb | Distal (>10kb) Multiome | 414 | |
| chr4:152,735,720–152,736,367 | 43.9 kb | Distal (>10kb) Multiome | 141 | |
| chr4:152,772,273–152,773,216 | 6.7 kb | Proximal (<10kb) | 61 | |
| chr4:152,779,006–152,780,778 | 88 bp | At TSS Multiome | 903 | |
| chr4:152,808,636–152,809,308 | 29.0 kb | Distal (>10kb) Multiome | 113 | |
| chr4:152,935,635–152,938,175 | 156.3 kb | Distal (>10kb) Multiome | 620 | |
| chr4:152,956,599–152,958,298 | 177.9 kb | Distal (>10kb) Multiome | 369 | |
| chr4:153,125,863–153,126,388 | 346.2 kb | Distal (>10kb) Multiome HiCAR | 64 |
Genomic view of the ARFIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.