ARFGEF2

ARF guanine nucleotide exchange factor 2 | BIG2

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Member of: DE-3 DE-3.8

Biological processes 55 terms

GABA receptor binding (GO:0050811)GABA receptor binding (GO:0050811)GABA-ergic synapse (GO:0098982)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi to plasma membrane transport (GO:0006893)Golgi to plasma membrane transport (GO:0006893)asymmetric synapse (GO:0032279)asymmetric synapse (GO:0032279)axonemal microtubule (GO:0005879)axonemal microtubule (GO:0005879)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoskeleton (GO:0005856)cytosol (GO:0005829)dendrite (GO:0030425)dendritic spine (GO:0043197)dendritic spine (GO:0043197)endomembrane system organization (GO:0010256)endomembrane system organization (GO:0010256)endosome (GO:0005768)endosome organization (GO:0007032)endosome organization (GO:0007032)exocytosis (GO:0006887)exocytosis (GO:0006887)glutamatergic synapse (GO:0098978)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)intracellular signal transduction (GO:0035556)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)microtubule organizing center (GO:0005815)myosin binding (GO:0017022)perinuclear region of cytoplasm (GO:0048471)positive regulation of tumor necrosis factor production (GO:0032760)postsynapse (GO:0098794)presynapse (GO:0098793)protein binding (GO:0005515)protein kinase A regulatory subunit binding (GO:0034237)protein kinase A regulatory subunit binding (GO:0034237)receptor recycling (GO:0001881)recycling endosome (GO:0055037)regulation of ARF protein signal transduction (GO:0032012)symmetric synapse (GO:0032280)symmetric synapse (GO:0032280)synapse (GO:0045202)trans-Golgi network (GO:0005802)trans-Golgi network (GO:0005802)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating ARFGEF2 0 TFs

Transcription factors with Perturb-seq knockdown data for ARFGEF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFGEF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARFGEF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFGEF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:48,751,156–48,751,799	170.3 kb	Distal (>10kb) Multiome	254
chr20:48,825,950–48,828,654	95.4 kb	Distal (>10kb) Multiome	682
chr20:48,846,443–48,846,926	75.1 kb	Distal (>10kb) Multiome	257
chr20:48,858,252–48,858,759	63.1 kb	Distal (>10kb) Multiome	100
chr20:48,921,125–48,922,305	at TSS	At TSS Multiome	1077
chr20:48,931,717–48,932,241	9.9 kb	Proximal (<10kb)	96
chr20:49,045,736–49,047,213	124.8 kb	Distal (>10kb) Multiome	1069
chr20:49,187,732–49,189,017	266.7 kb	Distal (>10kb) Multiome	893
chr20:49,218,926–49,220,026	297.6 kb	Distal (>10kb) Multiome	836

Genome Browser

Genomic view of the ARFGEF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.