Transcription factors with Perturb-seq knockdown data for AQP4-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AQP4-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AQP4-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:26,457,727–26,458,252 | 197.6 kb | Distal (>10kb) Multiome | 110 | |
| chr18:26,546,875–26,550,290 | 107.2 kb | Distal (>10kb) Multiome | 641 | |
| chr18:26,550,411–26,551,223 | 104.7 kb | Distal (>10kb) Multiome | 242 | |
| chr18:26,648,070–26,650,001 | 6.5 kb | Proximal (<10kb) Multiome | 408 | |
| chr18:26,650,889–26,651,492 | 4.6 kb | Proximal (<10kb) Multiome | 74 | |
| chr18:26,655,726–26,657,561 | 1.5 kb | Proximal (<10kb) Multiome | 533 | |
| chr18:26,664,459–26,664,656 | 8.7 kb | Proximal (<10kb) | 8 | |
| chr18:26,709,971–26,711,052 | 54.8 kb | Distal (>10kb) Multiome | 287 | |
| chr18:26,863,119–26,863,780 | 207.7 kb | Distal (>10kb) Multiome | 279 |
Genomic view of the AQP4-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.