Transcription factors with Perturb-seq knockdown data for APPBP2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APPBP2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APPBP2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:60,327,303–60,327,917 | 198.6 kb | Distal (>10kb) Multiome | 115 | |
| chr17:60,384,860–60,385,543 | 141.1 kb | Distal (>10kb) Multiome | 76 | |
| chr17:60,391,203–60,392,936 | 134.0 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:60,421,283–60,422,169 | 104.7 kb | Distal (>10kb) Multiome | 479 | |
| chr17:60,525,577–60,526,500 | 133 bp | At TSS Multiome | 955 | |
| chr17:60,579,473–60,580,626 | 53.6 kb | Distal (>10kb) Multiome | 205 | |
| chr17:60,599,336–60,601,434 | 73.8 kb | Distal (>10kb) Multiome | 1120 | |
| chr17:60,676,921–60,678,448 | 151.4 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the APPBP2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.