AP5B1

adaptor related protein complex 5 subunit beta 1 | AP-5, DKFZp761E198, PP1030

Involved in endosomal transport. Located in lysosomal membrane. Part of AP-type membrane coat adaptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 11 terms

AP-type membrane coat adaptor complex (GO:0030119)AP-type membrane coat adaptor complex (GO:0030119)endosomal transport (GO:0016197)endosomal transport (GO:0016197)endosomal transport (GO:0016197)late endosome (GO:0005770)lysosomal membrane (GO:0005765)lysosome (GO:0005764)lysosome organization (GO:0007040)protein binding (GO:0005515)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating AP5B1 0 TFs

Transcription factors with Perturb-seq knockdown data for AP5B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP5B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AP5B1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP5B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:65,487,451–65,488,490	293.2 kb	Distal (>10kb) Multiome	706
chr11:65,496,515–65,498,726	283.4 kb	Distal (>10kb) Multiome	1059
chr11:65,506,702–65,508,865	273.7 kb	Distal (>10kb) Multiome	864
chr11:65,524,475–65,525,724	256.0 kb	Distal (>10kb) Multiome	711
chr11:65,538,923–65,541,339	240.1 kb	Distal (>10kb) Multiome	733
chr11:65,546,285–65,547,091	234.3 kb	Distal (>10kb) Multiome	529
chr11:65,553,318–65,554,003	227.3 kb	Distal (>10kb) Multiome	195
chr11:65,569,718–65,570,745	210.7 kb	Distal (>10kb) Multiome	930
chr11:65,571,973–65,573,008	208.5 kb	Distal (>10kb) Multiome	420
chr11:65,573,788–65,575,269	206.6 kb	Distal (>10kb) Multiome	742
chr11:65,575,601–65,576,322	205.0 kb	Distal (>10kb) Multiome	527
chr11:65,591,808–65,592,698	188.8 kb	Distal (>10kb) Multiome	169
chr11:65,606,536–65,607,917	173.8 kb	Distal (>10kb) Multiome	376
chr11:65,613,478–65,614,645	166.8 kb	Distal (>10kb) Multiome	702
chr11:65,614,954–65,616,793	165.4 kb	Distal (>10kb) Multiome	830
chr11:65,637,768–65,638,920	142.9 kb	Distal (>10kb) Multiome	740
chr11:65,641,918–65,642,633	138.8 kb	Distal (>10kb) Multiome	155
chr11:65,646,814–65,647,818	133.7 kb	Distal (>10kb) Multiome	270
chr11:65,652,106–65,653,317	128.2 kb	Distal (>10kb) Multiome	901
chr11:65,662,517–65,663,930	117.9 kb	Distal (>10kb) Multiome	839
chr11:65,711,437–65,712,942	68.7 kb	Distal (>10kb) Multiome	1143
chr11:65,720,215–65,720,955	60.3 kb	Distal (>10kb) Multiome	821
chr11:65,779,808–65,781,988	908 bp	At TSS Multiome	764
chr11:65,785,898–65,789,101	7.4 kb	Proximal (<10kb) Multiome	478
chr11:65,817,968–65,818,502	37.3 kb	Distal (>10kb) Multiome	694
chr11:65,833,325–65,834,189	52.8 kb	Distal (>10kb) Multiome	396
chr11:65,856,804–65,858,748	76.1 kb	Distal (>10kb) Multiome	972
chr11:65,859,034–65,861,240	79.6 kb	Distal (>10kb) Multiome	1012
chr11:65,871,920–65,874,072	92.7 kb	Distal (>10kb) Multiome	741
chr11:65,887,987–65,889,162	107.6 kb	Distal (>10kb) Multiome	824
chr11:65,890,253–65,891,457	109.7 kb	Distal (>10kb) Multiome	895
chr11:65,899,867–65,900,779	119.6 kb	Distal (>10kb) Multiome	740
chr11:65,918,507–65,920,266	138.3 kb	Distal (>10kb) Multiome	992
chr11:65,961,271–65,962,172	180.7 kb	Distal (>10kb) Multiome	834
chr11:66,001,882–66,002,962	221.4 kb	Distal (>10kb) Multiome	1022
chr11:66,007,227–66,007,703	226.5 kb	Distal (>10kb) Multiome	100
chr11:66,022,341–66,022,903	241.6 kb	Distal (>10kb) Multiome	466
chr11:66,045,170–66,045,637	264.4 kb	Distal (>10kb) Multiome	394
chr11:66,048,912–66,049,460	268.2 kb	Distal (>10kb) Multiome	83
chr11:66,051,716–66,052,760	271.2 kb	Distal (>10kb) Multiome	901
chr11:66,069,690–66,071,102	289.2 kb	Distal (>10kb) Multiome	622

Genome Browser

Genomic view of the AP5B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.