This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for AP1S3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1S3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1S3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:223,617,919–223,619,065 | 219.0 kb | Distal (>10kb) Multiome | 295 | |
| chr2:223,723,416–223,724,371 | 113.5 kb | Distal (>10kb) Multiome | 239 | |
| chr2:223,836,057–223,836,384 | 1.2 kb | Proximal (<10kb) | 193 | |
| chr2:223,836,841–223,838,450 | 42 bp | At TSS Multiome | 742 | |
| chr2:223,944,141–223,945,550 | 107.7 kb | Distal (>10kb) Multiome | 1001 | |
| chr2:223,947,302–223,948,205 | 110.3 kb | Distal (>10kb) Multiome | 107 | |
| chr2:223,952,061–223,952,791 | 114.8 kb | Distal (>10kb) Multiome | 152 | |
| chr2:223,956,992–223,957,891 | 119.8 kb | Distal (>10kb) Multiome | 1093 | |
| chr2:224,026,729–224,027,840 | 189.7 kb | Distal (>10kb) Multiome | 186 | |
| chr2:224,038,254–224,040,391 | 201.9 kb | Distal (>10kb) Multiome | 665 | |
| chr2:224,088,581–224,089,375 | 251.4 kb | Distal (>10kb) Multiome | 58 | |
| chr2:224,091,133–224,092,389 | 254.3 kb | Distal (>10kb) Multiome | 112 |
Genomic view of the AP1S3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.