This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for ANLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:36,112,818–36,113,397 | 276.7 kb | Distal (>10kb) Multiome | 87 | |
| chr7:36,152,317–36,154,017 | 236.9 kb | Distal (>10kb) Multiome | 781 | |
| chr7:36,258,280–36,258,762 | 131.2 kb | Distal (>10kb) Multiome | 236 | |
| chr7:36,278,017–36,278,924 | 111.5 kb | Distal (>10kb) Multiome | 133 | |
| chr7:36,280,728–36,281,576 | 108.6 kb | Distal (>10kb) Multiome | 293 | |
| chr7:36,317,138–36,318,414 | 72.3 kb | Distal (>10kb) Multiome | 28 | |
| chr7:36,366,649–36,367,847 | 22.6 kb | Distal (>10kb) Multiome | 792 | |
| chr7:36,388,932–36,390,769 | 1 bp | At TSS Multiome | 1029 |
Genomic view of the ANLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.