Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKS1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKS1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKS1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:34,696,215–34,697,266 | 192.4 kb | Distal (>10kb) Multiome | 892 | |
| chr6:34,756,834–34,757,760 | 131.9 kb | Distal (>10kb) Multiome | 983 | |
| chr6:34,791,487–34,792,569 | 97.3 kb | Distal (>10kb) Multiome | 857 | |
| chr6:34,887,730–34,888,431 | 1.3 kb | Proximal (<10kb) Multiome | 902 | |
| chr6:34,888,934–34,889,909 | 19 bp | At TSS Multiome | 749 | |
| chr6:35,141,228–35,141,736 | 252.1 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the ANKS1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.