Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ANKRD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:89,145,740–89,146,828 | 286.9 kb | Distal (>10kb) Multiome | 853 | |
| chr6:89,242,677–89,243,345 | 190.1 kb | Distal (>10kb) Multiome | 160 | |
| chr6:89,311,590–89,312,158 | 121.2 kb | Distal (>10kb) Multiome | 214 | |
| chr6:89,352,138–89,353,410 | 80.4 kb | Distal (>10kb) Multiome | 882 | |
| chr6:89,411,134–89,412,806 | 21.2 kb | Distal (>10kb) Multiome | 540 | |
| chr6:89,426,092–89,426,316 | 6.9 kb | Proximal (<10kb) | 1 | |
| chr6:89,432,777–89,434,173 | 32 bp | At TSS Multiome | 524 | |
| chr6:89,483,120–89,483,667 | 50.3 kb | Distal (>10kb) Multiome | 199 | |
| chr6:89,492,246–89,492,527 | 8.8 kb | Proximal (<10kb) | 22 | |
| chr6:89,493,449–89,494,745 | 61.0 kb | Distal (>10kb) Multiome | 266 | |
| chr6:89,496,006–89,496,706 | 63.1 kb | Distal (>10kb) Multiome | 166 | |
| chr6:89,522,599–89,523,543 | 89.9 kb | Distal (>10kb) Multiome | 138 | |
| chr6:89,588,903–89,590,722 | 157.1 kb | Distal (>10kb) Multiome HiCAR | 245 | |
| chr6:89,638,049–89,639,180 | 205.5 kb | Distal (>10kb) Multiome HiCAR | 783 |
Genomic view of the ANKRD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.