Predicted to enable NF-kappaB binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity and positive regulation of cytokine production involved in inflammatory response. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKRD42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,899,722–82,902,187 | 292.0 kb | Distal (>10kb) Multiome HiCAR | 1001 | |
| chr11:82,970,431–82,971,628 | 222.9 kb | Distal (>10kb) Multiome | 188 | |
| chr11:83,034,012–83,034,897 | 159.2 kb | Distal (>10kb) Multiome | 343 | |
| chr11:83,071,319–83,072,558 | 121.8 kb | Distal (>10kb) Multiome | 943 | |
| chr11:83,144,373–83,145,287 | 48.9 kb | Distal (>10kb) Multiome | 76 | |
| chr11:83,156,155–83,158,430 | 36.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr11:83,193,357–83,194,770 | 10 bp | At TSS Multiome | 817 | |
| chr11:83,241,143–83,241,871 | 47.8 kb | Distal (>10kb) Multiome | 285 | |
| chr11:83,285,491–83,286,808 | 92.5 kb | Distal (>10kb) Multiome | 1057 | |
| chr11:83,318,271–83,319,586 | 125.2 kb | Distal (>10kb) Multiome | 190 | |
| chr11:83,443,851–83,444,454 | 250.4 kb | Distal (>10kb) Multiome | 56 | |
| chr11:83,836,349–83,837,522 | 643.1 kb | Distal (>10kb) Multiome HiCAR | 244 |
Genomic view of the ANKRD42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.