Transcription factors with Perturb-seq knockdown data for ANKRD33B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD33B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD33B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:10,307,259–10,308,125 | 256.5 kb | Distal (>10kb) Multiome | 733 | |
| chr5:10,332,886–10,333,985 | 230.8 kb | Distal (>10kb) Multiome | 288 | |
| chr5:10,352,751–10,354,487 | 210.6 kb | Distal (>10kb) Multiome | 1042 | |
| chr5:10,441,055–10,442,455 | 122.4 kb | Distal (>10kb) Multiome | 721 | |
| chr5:10,514,072–10,514,528 | 50.1 kb | Distal (>10kb) Multiome | 182 | |
| chr5:10,562,689–10,565,568 | 110 bp | At TSS Multiome | 622 | |
| chr5:10,627,273–10,628,369 | 63.6 kb | Distal (>10kb) Multiome | 678 | |
| chr5:10,637,215–10,638,114 | 73.3 kb | Distal (>10kb) Multiome | 155 | |
| chr5:10,760,531–10,762,133 | 197.0 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the ANKRD33B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.