Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endocytic recycling and negative regulation of SNARE complex assembly. Acts upstream of or within early endosome to late endosome transport. Located in several cellular components, including cytosol; endosome; and lysosome. Implicated in eosinophilic esophagitis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKRD27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:32,403,163–32,403,921 | 271.7 kb | Distal (>10kb) Multiome | 151 | |
| chr19:32,405,092–32,406,553 | 269.4 kb | Distal (>10kb) Multiome | 914 | |
| chr19:32,580,669–32,581,896 | 94.0 kb | Distal (>10kb) Multiome | 774 | |
| chr19:32,674,338–32,676,683 | 131 bp | At TSS Multiome | 792 | |
| chr19:32,677,541–32,678,077 | 2.4 kb | Proximal (<10kb) | 113 | |
| chr19:32,691,659–32,692,482 | 16.8 kb | Distal (>10kb) Multiome | 839 | |
| chr19:32,701,845–32,702,627 | 27.1 kb | Distal (>10kb) Multiome | 257 | |
| chr19:32,706,824–32,707,422 | 31.9 kb | Distal (>10kb) Multiome | 106 | |
| chr19:32,971,721–32,972,560 | 296.9 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the ANKRD27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.