ALDOC

aldolase, fructose-bisphosphate C

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Developmental clusters: GC3

Biological processes 23 terms

canonical glycolysis (GO:0061621)cytoskeletal protein binding (GO:0008092)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)epithelial cell differentiation (GO:0030855)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)fructose 1,6-bisphosphate metabolic process (GO:0030388)fructose 1,6-bisphosphate metabolic process (GO:0030388)fructose metabolic process (GO:0006000)fructose-bisphosphate aldolase activity (GO:0004332)fructose-bisphosphate aldolase activity (GO:0004332)fructose-bisphosphate aldolase activity (GO:0004332)fructose-bisphosphate aldolase activity (GO:0004332)gluconeogenesis (GO:0006094)gluconeogenesis (GO:0006094)glycolytic process (GO:0006096)glycolytic process (GO:0006096)protein binding (GO:0005515)secretory granule lumen (GO:0034774)tertiary granule lumen (GO:1904724)

Expression (TPM)

TFs regulating ALDOC 0 TFs

Transcription factors with Perturb-seq knockdown data for ALDOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ALDOC

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:28,317,975–28,319,646	257.8 kb	Distal (>10kb) Multiome	858
chr17:28,321,010–28,321,937	255.5 kb	Distal (>10kb) Multiome	25
chr17:28,335,024–28,336,772	241.3 kb	Distal (>10kb) Multiome	933
chr17:28,357,059–28,357,929	219.3 kb	Distal (>10kb) Multiome	878
chr17:28,371,118–28,372,519	205.4 kb	Distal (>10kb) Multiome	532
chr17:28,381,316–28,381,844	195.3 kb	Distal (>10kb) Multiome	159
chr17:28,405,673–28,406,384	170.9 kb	Distal (>10kb) Multiome	591
chr17:28,466,531–28,467,034	110.1 kb	Distal (>10kb) Multiome	179
chr17:28,551,965–28,553,140	24.3 kb	Distal (>10kb) Multiome	557
chr17:28,570,861–28,571,983	5.3 kb	Proximal (<10kb) Multiome	701
chr17:28,576,649–28,577,524	100 bp	At TSS Multiome	652
chr17:28,598,491–28,599,842	22.2 kb	Distal (>10kb) Multiome	810
chr17:28,621,936–28,622,562	45.5 kb	Distal (>10kb) Multiome	55
chr17:28,644,541–28,645,596	68.3 kb	Distal (>10kb) Multiome	795
chr17:28,661,635–28,662,527	85.2 kb	Distal (>10kb) Multiome	809
chr17:28,710,720–28,712,813	134.5 kb	Distal (>10kb) Multiome	892
chr17:28,717,030–28,718,784	141.0 kb	Distal (>10kb) Multiome	492
chr17:28,718,918–28,720,313	142.9 kb	Distal (>10kb) Multiome	927
chr17:28,724,652–28,729,474	150.2 kb	Distal (>10kb) Multiome	1286
chr17:28,743,083–28,744,926	167.2 kb	Distal (>10kb) Multiome	991
chr17:28,745,076–28,746,436	168.7 kb	Distal (>10kb) Multiome	568
chr17:28,749,859–28,750,549	173.3 kb	Distal (>10kb) Multiome	550
chr17:28,811,615–28,812,945	235.6 kb	Distal (>10kb) Multiome	699
chr17:28,842,307–28,843,098	265.9 kb	Distal (>10kb) Multiome	717
chr17:28,854,460–28,855,289	278.0 kb	Distal (>10kb) Multiome	780

Genome Browser

Genomic view of the ALDOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.