This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for ALDH16A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDH16A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDH16A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,157,555–49,158,336 | 295.4 kb | Distal (>10kb) Multiome | 599 | |
| chr19:49,210,032–49,211,225 | 242.7 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,337,997–49,340,482 | 114.0 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 91.7 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 89.5 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 49.3 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 20.7 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 16.7 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 11.7 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 10.3 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,447,537–49,447,812 | 5.4 kb | Proximal (<10kb) | 105 | |
| chr19:49,451,347–49,452,239 | 1.4 kb | Proximal (<10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 147 bp | At TSS Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 23.2 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 34.2 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 43.0 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,500,403–49,501,353 | 47.5 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,512,565–49,513,700 | 59.8 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 74.7 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 80.8 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 102.9 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 127.4 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 140.3 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 185.1 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 187.2 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 211.3 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 212.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 219.2 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 223.7 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 227.5 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 237.9 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 293.2 kb | Distal (>10kb) Multiome | 283 |
Genomic view of the ALDH16A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.