The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AKAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:56,833,054–56,835,255 | 251.3 kb | Distal (>10kb) Multiome | 970 | |
| chr17:56,913,307–56,914,659 | 171.2 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:56,960,529–56,961,254 | 124.3 kb | Distal (>10kb) Multiome | 955 | |
| chr17:56,977,708–56,978,393 | 107.2 kb | Distal (>10kb) Multiome | 552 | |
| chr17:57,084,539–57,086,640 | 113 bp | At TSS Multiome | 1152 | |
| chr17:57,099,741–57,100,357 | 14.8 kb | Distal (>10kb) Multiome | 119 | |
| chr17:57,255,753–57,257,084 | 171.1 kb | Distal (>10kb) Multiome | 661 | |
| chr17:57,750,076–57,750,566 | 665.1 kb | Distal (>10kb) Multiome HiCAR | 85 | |
| chr17:57,756,756–57,757,413 | 671.9 kb | Distal (>10kb) Multiome HiCAR | 131 |
Genomic view of the AKAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.