The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for AK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:4,489,445–4,492,426 | 249.5 kb | Distal (>10kb) Multiome | 545 | |
| chr9:4,507,563–4,508,683 | 233.0 kb | Distal (>10kb) Multiome | 213 | |
| chr9:4,514,255–4,515,200 | 226.3 kb | Distal (>10kb) Multiome | 105 | |
| chr9:4,661,662–4,663,256 | 78.9 kb | Distal (>10kb) Multiome | 925 | |
| chr9:4,678,800–4,680,345 | 61.6 kb | Distal (>10kb) Multiome | 960 | |
| chr9:4,739,238–4,739,473 | 1.8 kb | Proximal (<10kb) | 77 | |
| chr9:4,739,624–4,740,029 | 1.2 kb | Proximal (<10kb) | 82 | |
| chr9:4,740,523–4,742,116 | 60 bp | At TSS Multiome | 942 | |
| chr9:4,762,590–4,763,629 | 22.1 kb | Distal (>10kb) Multiome | 504 | |
| chr9:4,792,132–4,794,058 | 51.6 kb | Distal (>10kb) Multiome | 871 | |
| chr9:4,984,214–4,986,401 | 243.9 kb | Distal (>10kb) Multiome | 981 | |
| chr9:5,437,323–5,438,772 | 696.6 kb | Distal (>10kb) Multiome HiCAR | 858 | |
| chr9:5,450,352–5,451,061 | 709.3 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr9:5,628,133–5,629,918 | 887.7 kb | Distal (>10kb) Multiome HiCAR | 812 |
Genomic view of the AK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.