This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AGTRAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGTRAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGTRAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,478,503–11,480,383 | 257.1 kb | Distal (>10kb) Multiome | 732 | |
| chr1:11,563,348–11,564,005 | 172.4 kb | Distal (>10kb) Multiome | 272 | |
| chr1:11,650,273–11,650,925 | 85.6 kb | Distal (>10kb) Multiome | 495 | |
| chr1:11,653,905–11,655,506 | 81.4 kb | Distal (>10kb) Multiome | 476 | |
| chr1:11,663,895–11,664,883 | 71.9 kb | Distal (>10kb) Multiome | 644 | |
| chr1:11,680,428–11,681,928 | 54.9 kb | Distal (>10kb) Multiome | 820 | |
| chr1:11,682,348–11,682,757 | 53.4 kb | Distal (>10kb) Multiome | 94 | |
| chr1:11,690,815–11,692,563 | 44.4 kb | Distal (>10kb) Multiome | 361 | |
| chr1:11,735,752–11,736,686 | 37 bp | At TSS Multiome | 714 | |
| chr1:11,736,819–11,737,044 | 690 bp | At TSS | 329 | |
| chr1:11,784,926–11,785,439 | 49.2 kb | Distal (>10kb) Multiome | 531 | |
| chr1:11,802,827–11,804,002 | 67.5 kb | Distal (>10kb) Multiome | 507 | |
| chr1:11,805,133–11,806,702 | 69.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:11,876,145–11,876,721 | 140.3 kb | Distal (>10kb) Multiome | 56 | |
| chr1:11,907,175–11,910,389 | 172.3 kb | Distal (>10kb) Multiome | 1299 | |
| chr1:11,925,969–11,926,788 | 190.4 kb | Distal (>10kb) Multiome | 632 | |
| chr1:11,934,261–11,935,008 | 198.5 kb | Distal (>10kb) Multiome | 809 | |
| chr1:11,979,601–11,980,894 | 244.2 kb | Distal (>10kb) Multiome | 932 | |
| chr1:12,019,010–12,020,110 | 283.3 kb | Distal (>10kb) Multiome | 841 |
Genomic view of the AGTRAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.