This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for AGPAT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGPAT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGPAT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:6,559,766–6,561,284 | 148.1 kb | Distal (>10kb) Multiome HiCAR | 551 | |
| chr8:6,562,645–6,563,524 | 145.4 kb | Distal (>10kb) Multiome HiCAR | 199 | |
| chr8:6,699,363–6,700,087 | 8.6 kb | Proximal (<10kb) | 41 | |
| chr8:6,706,385–6,706,763 | 1.9 kb | Proximal (<10kb) | 184 | |
| chr8:6,707,768–6,709,358 | 251 bp | At TSS Multiome | 1010 | |
| chr8:6,800,522–6,801,235 | 92.3 kb | Distal (>10kb) Multiome | 483 | |
| chr8:6,834,068–6,835,901 | 126.9 kb | Distal (>10kb) Multiome | 395 | |
| chr8:6,840,478–6,841,374 | 132.3 kb | Distal (>10kb) Multiome | 350 | |
| chr8:6,863,803–6,864,675 | 155.3 kb | Distal (>10kb) Multiome | 77 |
Genomic view of the AGPAT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.