The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for AFAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AFAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AFAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:7,719,478–7,720,023 | 220.2 kb | Distal (>10kb) Multiome | 197 | |
| chr4:7,938,744–7,938,923 | 1.0 kb | Proximal (<10kb) | 188 | |
| chr4:7,939,217–7,940,166 | 14 bp | At TSS Multiome | 474 | |
| chr4:7,948,661–7,949,576 | 9.1 kb | Proximal (<10kb) Multiome | 121 | |
| chr4:8,050,303–8,051,028 | 110.8 kb | Distal (>10kb) Multiome | 456 | |
| chr4:8,157,851–8,159,668 | 219.0 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the AFAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.