Enables DNA exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AEN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AEN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AEN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,388,191–88,389,364 | 232.5 kb | Distal (>10kb) Multiome | 280 | |
| chr15:88,467,068–88,468,013 | 153.8 kb | Distal (>10kb) Multiome | 857 | |
| chr15:88,537,723–88,539,073 | 82.7 kb | Distal (>10kb) Multiome | 141 | |
| chr15:88,545,733–88,547,888 | 74.8 kb | Distal (>10kb) Multiome | 818 | |
| chr15:88,571,230–88,572,235 | 49.6 kb | Distal (>10kb) Multiome | 149 | |
| chr15:88,604,930–88,605,917 | 15.6 kb | Distal (>10kb) Multiome | 530 | |
| chr15:88,610,494–88,611,216 | 10.5 kb | Distal (>10kb) Multiome | 201 | |
| chr15:88,612,843–88,613,762 | 8.0 kb | Proximal (<10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 6.6 kb | Proximal (<10kb) Multiome | 414 | |
| chr15:88,620,659–88,621,775 | 80 bp | At TSS Multiome | 829 | |
| chr15:88,624,261–88,624,659 | 2.9 kb | Proximal (<10kb) | 116 | |
| chr15:88,638,306–88,639,588 | 17.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr15:88,802,773–88,804,052 | 182.2 kb | Distal (>10kb) Multiome | 209 | |
| chr15:88,884,728–88,885,208 | 263.5 kb | Distal (>10kb) Multiome | 118 | |
| chr15:88,894,331–88,895,700 | 273.2 kb | Distal (>10kb) Multiome | 400 | |
| chr15:88,904,638–88,905,279 | 283.6 kb | Distal (>10kb) Multiome | 420 | |
| chr15:88,912,215–88,913,629 | 292.0 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the AEN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.