This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ADSS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADSS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADSS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,210,968–244,211,448 | 240.6 kb | Distal (>10kb) Multiome | 197 | |
| chr1:244,341,454–244,342,356 | 110.1 kb | Distal (>10kb) Multiome | 361 | |
| chr1:244,353,544–244,354,028 | 98.1 kb | Distal (>10kb) Multiome | 404 | |
| chr1:244,361,460–244,362,746 | 89.9 kb | Distal (>10kb) Multiome | 272 | |
| chr1:244,450,993–244,452,731 | 155 bp | At TSS Multiome | 958 | |
| chr1:244,454,544–244,454,889 | 2.6 kb | Proximal (<10kb) | 36 | |
| chr1:244,456,059–244,456,397 | 4.2 kb | Proximal (<10kb) | 14 | |
| chr1:244,461,143–244,461,971 | 9.5 kb | Proximal (<10kb) Multiome | 511 | |
| chr1:244,651,947–244,654,106 | 201.1 kb | Distal (>10kb) Multiome | 921 | |
| chr1:244,730,143–244,731,325 | 278.8 kb | Distal (>10kb) Multiome | 295 | |
| chr1:244,815,498–244,816,101 | 363.8 kb | Distal (>10kb) Multiome HiCAR | 177 |
Genomic view of the ADSS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.