This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for ADGRL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:13,861,855–13,862,533 | 299.2 kb | Distal (>10kb) Multiome | 655 | |
| chr19:13,872,706–13,873,325 | 288.5 kb | Distal (>10kb) Multiome | 254 | |
| chr19:13,879,942–13,880,779 | 281.2 kb | Distal (>10kb) Multiome | 780 | |
| chr19:13,905,895–13,906,734 | 255.4 kb | Distal (>10kb) Multiome | 835 | |
| chr19:13,951,898–13,953,117 | 209.2 kb | Distal (>10kb) Multiome | 667 | |
| chr19:13,962,408–13,964,055 | 197.8 kb | Distal (>10kb) Multiome | 166 | |
| chr19:13,978,193–13,979,385 | 182.9 kb | Distal (>10kb) Multiome | 238 | |
| chr19:14,005,474–14,007,363 | 155.0 kb | Distal (>10kb) Multiome | 1098 | |
| chr19:14,031,574–14,032,483 | 129.4 kb | Distal (>10kb) Multiome | 726 | |
| chr19:14,057,383–14,057,841 | 103.8 kb | Distal (>10kb) Multiome | 244 | |
| chr19:14,071,936–14,072,417 | 89.3 kb | Distal (>10kb) Multiome | 676 | |
| chr19:14,072,991–14,073,911 | 87.9 kb | Distal (>10kb) Multiome | 589 | |
| chr19:14,081,022–14,082,024 | 80.1 kb | Distal (>10kb) Multiome | 806 | |
| chr19:14,089,535–14,092,049 | 70.5 kb | Distal (>10kb) Multiome | 766 | |
| chr19:14,117,519–14,118,617 | 43.6 kb | Distal (>10kb) Multiome | 734 | |
| chr19:14,136,079–14,137,770 | 24.6 kb | Distal (>10kb) Multiome | 978 | |
| chr19:14,206,623–14,207,699 | 45.7 kb | Distal (>10kb) Multiome | 444 | |
| chr19:14,247,378–14,248,008 | 86.1 kb | Distal (>10kb) Multiome | 109 | |
| chr19:14,248,166–14,249,635 | 87.2 kb | Distal (>10kb) Multiome | 230 | |
| chr19:14,264,813–14,266,130 | 103.9 kb | Distal (>10kb) Multiome | 223 | |
| chr19:14,294,831–14,295,420 | 133.6 kb | Distal (>10kb) Multiome | 60 | |
| chr19:14,363,590–14,364,020 | 202.2 kb | Distal (>10kb) Multiome | 402 | |
| chr19:14,405,442–14,406,893 | 244.6 kb | Distal (>10kb) Multiome HiCAR | 662 | |
| chr19:14,418,847–14,419,795 | 257.9 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr19:14,432,848–14,433,780 | 271.8 kb | Distal (>10kb) Multiome | 524 | |
| chr19:14,450,232–14,451,000 | 289.1 kb | Distal (>10kb) Multiome | 271 | |
| chr19:14,472,177–14,472,986 | 311.0 kb | Distal (>10kb) Multiome | 566 | |
| chr19:14,495,705–14,496,690 | 334.8 kb | Distal (>10kb) Multiome | 813 |
Genomic view of the ADGRL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.