Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ADAMTS9-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS9-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS9-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:64,444,744–64,445,851 | 239.7 kb | Distal (>10kb) Multiome | 328 | |
| chr3:64,489,031–64,490,029 | 195.6 kb | Distal (>10kb) Multiome | 232 | |
| chr3:64,649,591–64,650,867 | 34.9 kb | Distal (>10kb) Multiome | 252 | |
| chr3:64,676,859–64,677,175 | 7.9 kb | Proximal (<10kb) | 31 | |
| chr3:64,684,758–64,686,900 | 931 bp | At TSS Multiome | 510 | |
| chr3:64,687,325–64,689,155 | 2.9 kb | Proximal (<10kb) Multiome | 398 | |
| chr3:65,368,876–65,369,448 | 684.0 kb | Distal (>10kb) Multiome HiCAR | 51 |
Genomic view of the ADAMTS9-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.