ACVR2B

activin A receptor type 2B | ActR-IIB

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Member of: DE-7 DE-7.2

Biological processes 67 terms

ATP binding (GO:0005524)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)BMP signaling pathway (GO:0030509)activin binding (GO:0048185)activin binding (GO:0048185)activin receptor activity (GO:0017002)activin receptor activity, type II (GO:0016362)activin receptor activity, type II (GO:0016362)activin receptor activity, type II (GO:0016362)activin receptor complex (GO:0048179)activin receptor signaling pathway (GO:0032924)activin receptor signaling pathway (GO:0032924)anterior/posterior pattern specification (GO:0009952)artery development (GO:0060840)artery development (GO:0060840)blood vessel remodeling (GO:0001974)blood vessel remodeling (GO:0001974)cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)cellular response to growth factor stimulus (GO:0071363)cytoplasm (GO:0005737)developmental process (GO:0032502)growth factor binding (GO:0019838)growth factor binding (GO:0019838)intracellular iron ion homeostasis (GO:0006879)kinase activator activity (GO:0019209)lymphangiogenesis (GO:0001946)lymphangiogenesis (GO:0001946)lymphatic endothelial cell differentiation (GO:0060836)lymphatic endothelial cell differentiation (GO:0060836)membrane (GO:0016020)negative regulation of adipose tissue development (GO:1904178)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of ossification (GO:0030279)negative regulation of ossification (GO:0030279)negative regulation of transcription by RNA polymerase II (GO:0000122)pattern specification process (GO:0007389)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of activin receptor signaling pathway (GO:0032927)positive regulation of activin receptor signaling pathway (GO:0032927)positive regulation of bone mineralization (GO:0030501)positive regulation of bone mineralization (GO:0030501)positive regulation of osteoblast differentiation (GO:0045669)positive regulation of osteoblast differentiation (GO:0045669)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine/tyrosine kinase activity (GO:0004712)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)retina vasculature development in camera-type eye (GO:0061298)retina vasculature development in camera-type eye (GO:0061298)signal transduction (GO:0007165)signaling receptor complex (GO:0043235)signaling receptor complex (GO:0043235)transmembrane receptor protein serine/threonine kinase activity (GO:0004675)trophoblast cell migration (GO:0061450)venous blood vessel development (GO:0060841)venous blood vessel development (GO:0060841)

Expression (TPM)

TFs regulating ACVR2B 0 TFs

Transcription factors with Perturb-seq knockdown data for ACVR2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACVR2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ACVR2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACVR2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:38,136,419–38,139,307	315.1 kb	Distal (>10kb) Multiome HiCAR	989
chr3:38,164,619–38,166,160	288.6 kb	Distal (>10kb) Multiome	1040
chr3:38,345,594–38,347,388	107.1 kb	Distal (>10kb) Multiome HiCAR	971
chr3:38,452,852–38,456,220	174 bp	At TSS Multiome	971
chr3:38,495,771–38,496,881	42.5 kb	Distal (>10kb) Multiome	764
chr3:38,580,074–38,580,574	126.5 kb	Distal (>10kb) Multiome	109
chr3:38,601,761–38,602,426	148.2 kb	Distal (>10kb) Multiome	48
chr3:38,640,708–38,641,494	187.2 kb	Distal (>10kb) Multiome	182
chr3:38,649,012–38,650,212	195.8 kb	Distal (>10kb) Multiome	437
chr3:38,651,034–38,651,663	197.5 kb	Distal (>10kb) Multiome	351
chr3:38,669,439–38,670,183	215.9 kb	Distal (>10kb) Multiome	85

Genome Browser

Genomic view of the ACVR2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.