Enables propionate-CoA ligase activity. Predicted to be involved in ketone body biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACSS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACSS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACSS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:80,936,276–80,938,142 | 141.0 kb | Distal (>10kb) Multiome | 739 | |
| chr12:81,076,350–81,079,144 | 342 bp | At TSS Multiome | 720 | |
| chr12:81,079,251–81,079,582 | 1.2 kb | Proximal (<10kb) | 83 | |
| chr12:81,080,122–81,080,321 | 2.1 kb | Proximal (<10kb) | 50 | |
| chr12:81,080,485–81,081,097 | 2.4 kb | Proximal (<10kb) | 120 | |
| chr12:81,083,089–81,083,293 | 5.0 kb | Proximal (<10kb) | 8 | |
| chr12:81,083,953–81,084,139 | 5.9 kb | Proximal (<10kb) | 58 | |
| chr12:81,086,376–81,086,844 | 8.3 kb | Proximal (<10kb) | 343 |
Genomic view of the ACSS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.