Enables GTPase activator activity. Acts upstream of or within actin filament-based process. Located in ruffle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ACAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:194,632,897–194,634,022 | 809.5 kb | Distal (>10kb) Multiome HiCAR | 802 | |
| chr3:195,150,284–195,150,801 | 292.4 kb | Distal (>10kb) Multiome | 462 | |
| chr3:195,259,295–195,260,886 | 182.8 kb | Distal (>10kb) Multiome | 943 | |
| chr3:195,270,082–195,272,177 | 171.7 kb | Distal (>10kb) Multiome | 1024 | |
| chr3:195,297,445–195,298,276 | 145.1 kb | Distal (>10kb) Multiome | 66 | |
| chr3:195,442,104–195,443,858 | 131 bp | At TSS Multiome | 857 | |
| chr3:195,446,388–195,446,642 | 3.3 kb | Proximal (<10kb) | 24 | |
| chr3:195,542,767–195,544,250 | 100.3 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the ACAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.