Predicted to enable PDZ domain binding activity and protein heterodimerization activity. Predicted to act upstream of or within exploration behavior; glutamatergic synaptic transmission; and protein stabilization. Predicted to be located in glutamatergic synapse and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABTB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABTB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABTB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:107,092,776–107,094,398 | 224.6 kb | Distal (>10kb) Multiome | 884 | |
| chr12:107,317,739–107,321,052 | 132 bp | At TSS Multiome | 752 | |
| chr12:107,321,195–107,321,559 | 2.8 kb | Proximal (<10kb) | 233 | |
| chr12:107,580,999–107,581,602 | 262.9 kb | Distal (>10kb) Multiome | 125 | |
| chr12:107,609,968–107,610,492 | 291.8 kb | Distal (>10kb) Multiome | 91 | |
| chr12:107,634,992–107,635,543 | 316.9 kb | Distal (>10kb) Multiome | 94 | |
| chr12:107,645,427–107,646,365 | 327.6 kb | Distal (>10kb) Multiome | 246 | |
| chr12:107,685,428–107,686,240 | 367.3 kb | Distal (>10kb) Multiome | 930 | |
| chr12:107,760,460–107,761,864 | 442.8 kb | Distal (>10kb) Multiome | 768 | |
| chr12:107,775,288–107,775,778 | 457.1 kb | Distal (>10kb) Multiome | 233 | |
| chr12:107,843,356–107,844,974 | 526.2 kb | Distal (>10kb) Multiome | 255 | |
| chr12:107,864,203–107,864,687 | 546.1 kb | Distal (>10kb) Multiome | 117 | |
| chr12:107,903,668–107,904,167 | 585.4 kb | Distal (>10kb) Multiome | 469 | |
| chr12:107,912,390–107,913,032 | 594.3 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the ABTB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.