Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ABTB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABTB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABTB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:34,104,945–34,106,393 | 252.4 kb | Distal (>10kb) Multiome HiCAR | 1046 | |
| chr11:34,174,182–34,174,889 | 183.5 kb | Distal (>10kb) Multiome HiCAR | 634 | |
| chr11:34,236,421–34,237,093 | 121.2 kb | Distal (>10kb) Multiome | 194 | |
| chr11:34,262,742–34,263,988 | 94.4 kb | Distal (>10kb) Multiome | 426 | |
| chr11:34,302,438–34,303,315 | 55.1 kb | Distal (>10kb) Multiome | 271 | |
| chr11:34,309,995–34,310,608 | 47.7 kb | Distal (>10kb) Multiome | 187 | |
| chr11:34,356,485–34,359,534 | 141 bp | At TSS Multiome | 985 | |
| chr11:35,418,192–35,419,975 | 1061.4 kb | Distal (>10kb) Multiome HiCAR | 384 |
Genomic view of the ABTB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.