This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for ABHD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABHD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABHD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,802,773–88,804,052 | 284.9 kb | Distal (>10kb) Multiome | 209 | |
| chr15:88,884,728–88,885,208 | 203.6 kb | Distal (>10kb) Multiome | 118 | |
| chr15:88,894,331–88,895,700 | 193.9 kb | Distal (>10kb) Multiome | 400 | |
| chr15:88,904,638–88,905,279 | 183.5 kb | Distal (>10kb) Multiome | 420 | |
| chr15:88,912,215–88,913,629 | 175.1 kb | Distal (>10kb) Multiome | 632 | |
| chr15:88,982,989–88,983,702 | 105.3 kb | Distal (>10kb) Multiome | 90 | |
| chr15:88,985,799–88,986,383 | 102.3 kb | Distal (>10kb) Multiome | 269 | |
| chr15:88,987,948–88,988,725 | 100.1 kb | Distal (>10kb) Multiome | 239 | |
| chr15:88,998,974–88,999,579 | 89.2 kb | Distal (>10kb) Multiome | 139 | |
| chr15:89,017,417–89,018,078 | 70.7 kb | Distal (>10kb) Multiome | 478 | |
| chr15:89,087,643–89,089,226 | 172 bp | At TSS Multiome | 898 | |
| chr15:89,243,575–89,244,499 | 155.5 kb | Distal (>10kb) Multiome | 855 | |
| chr15:89,334,096–89,335,852 | 246.5 kb | Distal (>10kb) Multiome | 1109 | |
| chr15:89,358,633–89,359,313 | 270.4 kb | Distal (>10kb) Multiome | 569 | |
| chr15:89,367,305–89,368,054 | 279.2 kb | Distal (>10kb) Multiome | 267 | |
| chr15:89,371,087–89,371,852 | 283.1 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the ABHD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.