ABCC5

ATP binding cassette subfamily C member 5 | EST277145, MOAT-C, MRP5, SMRP

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Member of: DE-2 Developmental clusters: GC4

Biological processes 49 terms

ABC-type transporter activity (GO:0140359)ABC-type transporter activity (GO:0140359)ABC-type transporter activity (GO:0140359)ABC-type xenobiotic transporter activity (GO:0008559)ABC-type xenobiotic transporter activity (GO:0008559)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATPase-coupled transmembrane transporter activity (GO:0042626)Golgi lumen (GO:0005796)apical plasma membrane (GO:0016324)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)cAMP transport (GO:0070730)cGMP transport (GO:0070731)carbohydrate derivative transport (GO:1901264)efflux transmembrane transporter activity (GO:0015562)endosome membrane (GO:0010008)export across plasma membrane (GO:0140115)folate transmembrane transport (GO:0098838)glutathione transmembrane transport (GO:0034775)glutathione transmembrane transporter activity (GO:0034634)heme transmembrane transport (GO:0035351)heme transmembrane transporter activity (GO:0015232)hyaluronan biosynthetic process (GO:0030213)hyaluronan biosynthetic process (GO:0030213)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)purine nucleotide transmembrane transporter activity (GO:0015216)purine nucleotide transport (GO:0015865)transmembrane transport (GO:0055085)transmembrane transport (GO:0055085)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)transport across blood-brain barrier (GO:0150104)xenobiotic detoxification by transmembrane export across the plasma membrane (GO:1990961)xenobiotic metabolic process (GO:0006805)xenobiotic transmembrane transport (GO:0006855)xenobiotic transmembrane transporter activity (GO:0042910)xenobiotic transport (GO:0042908)xenobiotic transport (GO:0042908)

Expression (TPM)

TFs regulating ABCC5 0 TFs

Transcription factors with Perturb-seq knockdown data for ABCC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ABCC5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:183,824,588–183,826,123	192.3 kb	Distal (>10kb) Multiome	467
chr3:183,883,494–183,884,017	134.3 kb	Distal (>10kb) Multiome	83
chr3:183,884,110–183,885,311	133.0 kb	Distal (>10kb) Multiome	972
chr3:183,912,940–183,913,709	104.6 kb	Distal (>10kb) Multiome HiCAR	225
chr3:184,017,103–184,018,456	8 bp	At TSS Multiome	878
chr3:184,134,086–184,134,568	116.2 kb	Distal (>10kb) Multiome	732
chr3:184,134,801–184,135,887	117.5 kb	Distal (>10kb) Multiome	941
chr3:184,154,967–184,155,880	137.4 kb	Distal (>10kb) Multiome	580
chr3:184,174,432–184,175,524	156.9 kb	Distal (>10kb) Multiome	765
chr3:184,176,129–184,177,706	158.8 kb	Distal (>10kb) Multiome	480
chr3:184,185,411–184,187,065	168.1 kb	Distal (>10kb) Multiome	878
chr3:184,229,229–184,229,859	211.6 kb	Distal (>10kb) Multiome	409
chr3:184,236,026–184,236,474	218.3 kb	Distal (>10kb) Multiome	41
chr3:184,241,140–184,242,189	223.9 kb	Distal (>10kb) Multiome	700
chr3:184,248,652–184,250,567	231.8 kb	Distal (>10kb) Multiome	1061
chr3:184,259,723–184,260,497	242.1 kb	Distal (>10kb) Multiome	318
chr3:184,260,815–184,262,571	243.8 kb	Distal (>10kb) Multiome	511
chr3:184,298,591–184,299,718	281.2 kb	Distal (>10kb) Multiome	768
chr3:184,314,169–184,315,514	296.7 kb	Distal (>10kb) Multiome	761

Genome Browser

Genomic view of the ABCC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.